Rams vs. Cardinals Prediction, Odds, Pick For NFL Week 6

The Arizona Cardinals will visit the Los Angeles Rams on Sunday in a Week 6 NFL showdown on FOX.

Let’s take a look at the odds for Rams vs. Cardinals at FanDuel Sportsbook as of Oct. 18. 

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Moneyline

• Rams: -850
• Cardinals: +575

Spread

• Rams -12.5: -115
• Cardinals +12.5: -105

Over/Under

• Over 51.5: -115
• Under 51.5: -105

From FOX Sports Research: 

• NFL’s top offense: The Rams lead the league with 424.4 total yards per game, while Matthew Stafford leads all quarterbacks with 1,572 passing yards.
• Stafford staying hot: Stafford has thrown for at least 300 yards in four consecutive games, matching the longest streak of his career.
• Recent Rams shootouts: Los Angeles’ last two losses featured totals of 56 points against Denver and 71 against Buffalo.
• Arizona’s passing game showing life: Jacoby Brissett threw for a season-high 292 yards and three touchdowns against Detroit in Week 5.
• Reliable weapons: Puka Nacua averages 112.3 receiving yards per game, Davante Adams has four touchdown catches, and Arizona’s Trey McBride leads the NFL with 42 receptions.

How to Watch Rams vs. Cardinals

• Date: Sunday, Oct. 18, 2026
• Time: 4:05 p.m. ET
• TV: FOX
• Stream: Watch 3 days free on FOX One, FOXSports.com, FOX Sports App
• Location: SoFi Stadium, Inglewood, CA